Resultados obstétricos y perinatales asociados a la infección por COVID-19: una revisión de la literatura.

Gabriela Valentina Carmach Ananias, Camila Fernanda Escobar Jaramillo

Resumen


Objetivo: Determinar los resultados obstétricos y/o perinatales que se asocian a la infección por COVID-19, a través de una revisión de la literatura.

Metodología: Se realizó una búsqueda avanzada en Pubmed, relacionada con los conceptos paciente e intervención y con los resultados de 67 términos, entre ellos “pregnant”, “newborn”, “Covid-19”, “abortion” y “placental pathology”. Se aplicaron como filtro los años 2019 y 2020 y se encontraron 506 estudios que, a su vez, se filtraron por título, resumen y tipo de estudio, seleccionando aquellos cuya muestra fueran embarazadas y/o neonatos diagnosticados con COVID-19, y que reportaran resultados obstétricos y/o perinatales negativos. Finalmente, se seleccionaron 42.  

Resultados: Los resultados que destacan por prevalencia o severidad fueron: parto prematuro, patología placentaria, anticuerpos IgM y/o IgG para COVID-19 aumentados en gestantes y recién nacidos, estado fetal no tranquilizador, COVID-19(+) en leche materna, en líquido amniótico o hisopado vaginal, probable transmisión intraparto, ingreso a UCIN, mala perfusión vascular fetal o materna y cesárea por condición materna asociada al virus.

Conclusiones: Sugerimos instaurar medidas de prevención oportunas en las gestantes para evitar el contagio por COVID-19 durante y después de la gestación, con el propósito de evitar el riesgo de complicaciones asociadas al virus, las  que conllevan importantes consecuencias para la madre y/o el recién nacido.  


Texto completo:

PDF

Referencias


(1) Chen, L., Li, Q., Zheng, D., Jiang, H., Wei, Y., Zou, L., . . . Qiao, J. (17 de Abril de 2020). Clinical Characteristics of Pregnant Women with Covid-19 in Wuhan, China. NEJM Group Public Health Emergency Collection, 382(25). doi:10.1056/NEJMc2009226

(2) llington, S., Strid, P., Tong, V., Woodworth, K., Galang, R., Zambrano, L., . . . Gilboa, S. (Junio de 2020). Characteristics of Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-June 7, 2020. MMWR. Morbidity and mortality weekly report, 69(25), 769-775. doi:10.15585/mmwr.mm6925a1

(3) Schwartz, D. (17 de Marzo de 2020). An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes. Arch Pathol Lab Med, 144(7), 799–805. doi:10.5858/arpa.2020-0901-SA

(4) Cao, D., Heng, Y., Sun, G., Chen, J., Wei, X., Tang, F., . . . Zhao, Y. (1 de Junio de 2020). Clinical analysis of ten pregnant women with COVID-19 in Wuhan, China: A retrospective study. International Journal of Infectious Diseases, 95, 294-300. doi:10.1016/j.ijid.2020.04.047

(5) Vlachodimitropoulou, E., Vivanti, A., Shehata, N., Benachi, A., & Kinga, A. (13 de Abril de 2020). COVID‐19 and acute coagulopathy in pregnancy. Journal of Thrombosis and Haemostasis, 18(7), 1648-1652. doi:10.1111/jth.14856

(6) Ferrazi, E., Frigerio, L., Savasi, V., Vergani, P., Prefumo, F., Barresi, S., . . . Villa, U. (28 de Mayo de 2020). Vaginal delivery in SARS-CoV-2-infected pregnant women in Northern Italy: a retrospective analysis. BJOG : an international journal of obstetrics and gynaecology, 1-6. doi:10.1111/1471-0528.16278

(7) Zhu, H., Wang, L., Fang, C., Peng, S., Zhang, L., Chang, G., . . . Zhou, W. (Febrero de 2020). Clinical analysis of 10 neonates born to mothers with 2019-nCoV pneumonia. Translational Pediatrics, 9(1), 51-60. doi:10.21037/tp.2020.02.06

(8) Wu, Y., Liu, C., Dong, L., Zhang, C., Chen, Y., Liu, J., . . . Huang, H. (5 de Mayo de 2020). Coronavirus disease 2019 among pregnant Chinese women: case series data on the safety of vaginal birth and breastfeeding. BJOG: An International Journal of Obstetrics & Gynaecology, 127(9), 1109-1115. doi:10.1111/1471-0528.16276

(9) Zamaniyan, M., Ebadi, A., Aghajanpoor, S., Rahmani, Z., Haghshenas, M., & Azizi, S. (17 de Abril de 2020). Preterm delivery in pregnant woman with critical COVID‐19 pneumonia and vertical transmission. Wiley Public Health Emergency Collection. doi:10.1002/pd.5713

(10) Kirstman, M., Diambomba, Y., Poutanen, S., Malinowski, A., Vlachodimitropoulou, E., Parks, T., . . . Shah, P. (15 de Junio de 2020). Probable congenital SARS-CoV-2 infection in a neonate born to a woman with active SARS-CoV-2 infection. CMAJ, 192(24), E647- E650. doi:10.1503/cmaj.200821

(11) Zeng, H., Xu, C., Fan, J., Tang, Y., Deng, Q., Zhang, W., & Long, X. (26 de Marzo de 2020). Antibodies in Infants Born to Mothers With COVID-19 Pneumonia. JAMA Network, 323(18), 1848-1849. doi:10.1001/jama.2020.4861

(12) Brandt, J., Hill, J., Reddy, A., Schuster, M., Patrick, H., Rosen, T., . . . Ananth, C. (25 de

Septiembre de 2020). Epidemiology of COVID-19 in Pregnancy: Risk Factors and Associations with Adverse Maternal and Neonatal Outcomes. American Journal of Obstetrics and Gynecology. doi:10.1016/j.ajog.2020.09.043

(13) Baergen, R., & Heller, D. (12 de Mayo de 2020). Placental Pathology in Covid-19 Positive Mothers: Preliminary Findings. Pediatric and evelopmental Pathology, 23(3), 177-180. doi:10.1177/1093526620925569

(14) Kuhrt, K., McMicking, J., Nanda, S., Nelson-Piercy, C., Shennan, A. (8 de mayo de 2020). Placental abruption in a twin pregnancy at 32 weeks' gestation complicated by coronavirus disease 2019 without vertical transmission to the babies. American journal of obstetrics & gynecology MFM, 2(3), 100135. doi: 10.1016/j.ajogmf.2020.100135

(15) Pierce-Williams RAM, Burd J, Felder L, et al. (8 de mayo de 2020). Clinical course of severe and critical coronavirus disease 2019 in hospitalized pregnancies: a United States cohort study. Am J Obstet Gynecol MFM. 2020;2(3):100134. doi: 10.1016/j.ajogmf.2020.100134

(16) Penfield, C. A., Brubaker, S. G., Limaye, M. A., Lighter, J., Ratner, A. J., Thomas, K. M., Meyer, J. A., & Roman, A. S. (8 de mayo de 2020). Detection of severe acute respiratory syndrome coronavirus 2 in placental and fetal membrane samples. American journal of obstetrics & gynecology MFM, 2(3), 100133. doi: 10.1016/j.ajogmf.2020.100133

(17) Ng, K. F., Bandi, S., Bird, P. W., & Wei-Tze Tang, J. (Julio de 2020). COVID-19 in Neonates and Infants: Progression and Recovery. The Pediatric infectious disease journal, 39(7), e140–e142. 10.1097/INF.0000000000002738.

(18) Vallejo, V., & Ilagan, J. G. (Julio de 2020). A Postpartum Death Due to Coronavirus Disease 2019 (COVID-19) in the United States. Obstetrics and gynecology, 136(1), 52–55. doi: 10.1097/AOG.0000000000003950

(19) Blauvelt, C. A., Chiu, C., Donovan, A. L., Prahl, M., Shimotake, T. K., George, R. B., Schwartz, B. S., Farooqi, N. A., Ali, S. S., Cassidy, A., Gonzalez, J. M., & Gaw, S. L. (Julio de 2020). Acute Respiratory Distress Syndrome in a Preterm Pregnant Patient With Coronavirus Disease 2019 (COVID-19). Obstetrics and gynecology, 136(1), 46–51.doi: 10.1097/AOG.0000000000003949

(20) Martinelli, I., Ferrazzi, E., Ciavarella, A., Erra, R., Iurlaro, E., Ossola, M., Lombardi, A., Blasi, F., Mosca, F., & Peyvandi, F. (Abril de 2020). Pulmonary embolism in a young pregnant woman with COVID-19. Thrombosis research, 191, 36–37.doi: 10.1016/j.thromres.2020.04.022

(21) Kuusela, A., Nazir, M., Gimovsky, M. (3 de Abril de 2020). Two cases of coronavirus 2019-related cardiomyopathy in pregnancy. American journal of obstetrics & gynecology MFM, 2(2), 100113. doi: 10.1016/j.ajogmf.2020.100113

(22) Xu, L., Yang, Q., Shi, H., Lei, S., Liu, X., Zhu, Y., Wu, Q., Ding, X., Tian, Y., Hu, Q., Chen, F., Geng, Z., Zeng, X., Lin, L., Cai, X., Wu, M., Wang, Z., Wang, Z., Xia, G., & Wang, L. (28 de abril de 2020). Clinical presentations and outcomes of SARS-CoV-2 infected pneumonia in pregnant women and health status of their neonates. Science bulletin, 65(18), 1537–1542. doi: 10.1016/j.scib.2020.04.040

Patanè, L., Morotti, D., Giunta, M. R., Sigismondi, C., Piccoli, M. G., Frigerio, L., Mangili, G., Arosio, M., & Cornolti, G. (18 de mayo de 2020). Vertical transmission of coronavirus disease 2019: severe acute respiratory syndrome coronavirus 2 RNA on the fetal side of the placenta in pregnancies with coronavirus disease 2019-positive mothers and neonates at birth. American journal of obstetrics & gynecology MFM, 2(3), 100145. doi: 10.1016/j.ajogmf.2020.100145.

(24) Hu, X., Gao, J., Luo, X., Feng, L., Liu, W., Chen, J., Benachi, A., De Luca, D., & Chen, L. (Julio de 2020). Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vertical Transmission in Neonates Born to Mothers With Coronavirus Disease 2019 (COVID-19) Pneumonia. Obstetrics and gynecology, 136(1), 65–67. doi: 10.1097/AOG.0000000000003926

(25) Salvatori, G., De Rose, D. U., Concato, C., Alario, D., Olivini, N., Dotta, A., & Campana, A. (21 de abril de 2020). Managing COVID-19-Positive Maternal-Infant Dyads: An Italian Experience. Breastfeeding medicine: the official journal of the Academy of Breastfeeding Medicine, 15(5), 347–348. doi: 10.1089/bfm.2020.0095

(26) Alzamora, M. C., Paredes, T., Caceres, D., Webb, C. M., Valdez, L. M., & La Rosa, M. (18 de abril de 2020). Severe COVID-19 during Pregnancy and Possible Vertical Transmission. American journal of perinatology, 37(8), 861–865. doi: 10.1055/s-0040-1710050

(27) Khan, S., Jun, L., Nawsherwan, Siddique, R., Li, Y., Han, G., Xue, M., Nabi, G., & Liu, J. (8 de abril de 2020). Association of COVID-19 with pregnancy outcomes in health-care workers and general women. Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 26(6), 788–790.doi: 10.1016/j.cmi.2020.03.034

(28) hang, Z. J., Yu, X. J., Fu, T., Liu, Y., Jiang, Y., Yang, B. X., & Bi, Y. (18 de junio de 2020). Novel coronavirus infection in newborn babies aged <28 days in China. The European respiratory journal, 55(6), 2000697. doi: 10.1183/13993003.00697-2020

(29) Chen, Y., Peng, H., Wang, L., Zhao, Y., Zeng, L., Gao, H., & Liu, Y. (16 de marzo de 2020). Infants Born to Mothers With a New Coronavirus (COVID-19). Frontiers in pediatrics, 8, 104. doi: 10.3389/fped.2020.00104

(30) Zeng, L. K., Tao, X. W., Yuan, W. H., Wang, J., Liu, X., & Liu, Z. S. (2 de abril de 2020). Zhonghua er ke za zhi = Chinese journal of pediatrics, 58(4), 279–280. doi: 10.3760/cma.j.cn112140-20200212-00081

(31) Kamali Aghdam, M., Jafari, N., & Eftekhari, K. (1 de abril de 2020). Novel coronavirus in a 15-day-old neonate with clinical signs of sepsis, a case report. Infectious diseases (London, England), 52(6), 427–429. doi: 10.1080/23744235.2020.1747634

(32) Wang, Z., Wang, Z., & Xiong, G. (8 de junio de 2020). Clinical characteristics and laboratory results of pregnant women with COVID-19 in Wuhan, China. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 150(3), 312–317. Advance online publication. doi: 10.1002/ijgo.13265

(33) Dong, L., Tian, J., He, S., Zhu, C., Wang, J., Liu, C., & Yang, J. (12 de mayo de 2020). Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA, 323(18), 1846–1848. doi: 10.1001/jama.2020.4621

Liu, D., Li, L., Wu, X., Zheng, D., Wang, J., Yang, L., & Zheng, C. (Julio de 2020). Pregnancy and Perinatal Outcomes of Women With Coronavirus Disease (COVID-19) Pneumonia: A Preliminary Analysis. AJR. American journal of roentgenology, 215(1), 127–132. doi: 10.2214/AJR.20.23072

Chen, R., Zhang, Y., Huang, L., Cheng, B. H., Xia, Z. Y., & Meng, Q. T. (16 de marzo 2020). Safety and efficacy of different anesthetic regimens for parturients with COVID-19 undergoing Cesarean delivery: a case series of 17 patients. Sécurité et efficacité de différents modes d’anesthésie pour des parturientes infectées par la COVID-19 accouchant par césarienne : une série de 17 cas. Canadian journal of anaesthesia = Journal canadien d'anesthesie, 67(6), 655–663. doi: 10.1007/s12630-020-01630-7

Chen, S., Huang, B., Luo, D. J., Li, X., Yang, F., Zhao, Y., Nie, X., & Huang, B. X. (8 de mayo de 2020). Zhonghua bing li xue za zhi = Chinese journal of pathology, 49(5), 418–423. doi: 10.3760/cma.j.cn112151-20200225-00138

randt, J. S., Hill, J., Reddy, A., Schuster, M., Patrick, H. S., Rosen, T., Sauer, M. V., Boyle, C., & Ananth, C. V. (25 de septiembre de 2020). Epidemiology of coronavirus disease 2019 in pregnancy: risk factors and associations with adverse maternal and neonatal outcomes. American journal of obstetrics and gynecology, S0002-9378(20)31134-0. Advance online publication. doi:10.1016/j.ajog.2020.09.043

Prabhu, M., Cagino, K., Matthews, K. C., Friedlander, R. L., Glynn, S. M., Kubiak, J. M., Yang, Y. J., Zhao, Z., Baergen, R. N., DiPace, J. I., Razavi, A. S., Skupski, D. W., Snyder, J. R., Singh, H. K., Kalish, R. B., Oxford, C. M., & Riley, L. E. (13 de agosto de 2020). Pregnancy and postpartum outcomes in a universally tested population for SARS-CoV-2 in New York City: a prospective cohort study. BJOG : an international journal of obstetrics and gynaecology, 127(12), 1548–1556. doi:10.1111/1471-0528.16403

Ferraiolo, A., Barra, F., Kratochwila, C., Paudice, M., Vellone, V. G., Godano, E., Varesano, S., Noberasco, G., Ferrero, S., & Arioni, C. (22 de junio de 2020). Report of Positive Placental Swabs for SARS-CoV-2 in an Asymptomatic Pregnant Woman with COVID-19. Medicina (Kaunas, Lithuania), 56(6), 306.doi:10.3390/medicina56060306.

Nawsherwan, Khan, S., Nabi, G., Fan, C., & Wang, S. (22 de junio de 2020). Impact of COVID-19 Pneumonia on Neonatal Birth Outcomes. Indian journal of pediatrics, 87(8), 645–646. doi: 10.1007/s12098-020-03372-2

Mendoza, M., Garcia-Ruiz, I., Maiz, N., Rodo, C., Garcia-Manau, P., Serrano, B., Lopez-Martinez, R. M., Balcells, J., Fernandez-Hidalgo, N., Carreras, E., & Suy, A. (21 de junio de 2020). Pre-eclampsia-like syndrome induced by severe COVID-19: a prospective observational study. BJOG: an international journal of obstetrics and gynaecology, 127(11), 1374–1380. doi: 10.1111/1471-0528.16339

Futterman, I., Toaff, M., Navi, L., & Clare, C. A. (18 de junio de 2020). COVID-19 and HELLP: Overlapping Clinical Pictures in Two Gravid Patients. AJP reports, 10(2), e179–e182. doi: 10.1055/s-0040-1712978

Sentilhes, L., De Marcillac, F., Jouffrieau, C., Kuhn, P., Thuet, V., Hansmann, Y., Ruch, Y., Fafi-Kremer, S., & Deruelle, P. (15 de junio de 2020). Coronavirus disease 2019 in pregnancy was associated with maternal morbidity and preterm birth. American journal of obstetrics and gynecology, S0002-9378(20)30639-6. Advance online publication.doi: 10.1016/j.ajog.2020.06.022.

Shanes, E. D., Mithal, L. B., Otero, S., Azad, H. A., Miller, E. S., & Goldstein, J. A. (12 de mayo de 2020). Placental pathology in COVID-19. medRxiv : the preprint server for health sciences, 2020.05.08.20093229. doi: 10.1101/2020.05.08.20093229




DOI: https://doi.org/10.22370/rev.mat.1.2021.2509

Copyright (c) 2021 Matronería Actual