Evaluation of antimycobacterial activity from marine and freshwater microalgae

Duahmet A. Ruiz-Güereca, Alexei F. Licea-Navarro, M. del Pilar Sánchez-Saavedra


Tuberculosis is considered one of the most important epidemiological diseases worldwide. The current treatment for tuberculosis is a combination of antituberculosis drugs for at least 9 months. Nowadays, the search for new pharmacological agents for the treatment of tuberculosis is an urgent endeavor. Microalgae produce a wide variety of molecules that possess biological activities of pharmaceutical interest. Therefore, the objective of this work was to evaluate the antimycobacterial activity of hexane crude extracts of 6 microalgae: Chlamydomonas mexicana, Porphyridium cruentum, Isochrysis galbana, Rhodomonas sp., Aphanocapsa marina, and Nitzschia palea. All of the hexane extracts inhibited at least 90% of the growth of Mycobacterium tuberculosis H37Rv at a concentration of 100 μg ml-1. The hexane crude extract of I. galbana had the highest antimycobacterial activity displaying a percentage inhibition that was equal to that of the antituberculosis drug isoniazid and having a minimum inhibitory concentration of 50 μg ml-1. These findings demonstrate that microalgae are an excellent source for the search of novel antimycobacterial compounds.

Palabras clave

Tuberculosis; Microalgae; Crude extract; Tetrazolium microplate assay; Antimycobacterial activity

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DOI: https://doi.org/10.22370/rbmo.2019.54.1.1544

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