Interleukin-6 as a biomarker of treatment success for temporomandibular joint disorders
DOI:
https://doi.org/10.22370/asd.2020.1.0.2625Keywords:
Interleukin-6, Temporomandibular Disorders, TreatmentAbstract
Objective: To evaluate IL-6 level changes in synovial fluid (SF) in the temporomandibular joint (TMJ) post-treatment of temporomandibular disorders (TMD).
Material and Methods: In a first search, MeSH terms were used in Pubmed. A second one was conducted in Pubmed and the Cochrane Library, with MeSH terms and keywords in an advanced search. Inclusion criteria were all systematic reviews since 2015 on treatments for TMD, and clinical studies since 2015 where IL-6 levels were measured in SF post-treatment of TMD. Exclusion criteria were all studies where IL-6 levels were measured in plasma or joint tissue.
Results: In the first search, 41 results were obtained per title and abstract, of which 15 systematic reviews remained meeting the inclusion criteria. In a second search, 35 results were obtained, of which 28 were excluded by title and abstract as they were not pertinent. After full reading, three randomized clinical studies remained that met the inclusion criteria.
Conclusion: It is necessary to continue considering new therapeutic strategies to decrease levels of pro-inflammatory cytokines, where IL-6 might become a possible biomarker in TMD.
Downloads
Published
How to Cite
Issue
Section
License
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository, in a journal or publish it in a book), with an acknowledgment of its initial publication in this journal.
Authors are encouraged to post their work online (e.g., in their institutional repositories or on their website) only after publication online.
When uploading, disseminating or repurposing Open Access publications, the journal should be clearly identified as the original source and proper citation information provided. In addition to the Version of Record (final published version), authors should deposit the URL/DOI of their published article in any repository.
